Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
Post-translational modifications of histones that influence nucleosome dynamics
GD Bowman, MG Poirier - Chemical reviews, 2014 - ACS Publications
Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
Regulating the chromatin landscape: structural and mechanistic perspectives
B Bartholomew - Annual review of biochemistry, 2014 - annualreviews.org
A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell
development and differentiation. They are often the targets of cancer, neurological disorders …
development and differentiation. They are often the targets of cancer, neurological disorders …
INO80 exchanges H2A. Z for H2A by translocating on DNA proximal to histone dimers
ATP-dependent chromatin remodellers modulate nucleosome dynamics by mobilizing or
disassembling nucleosomes, as well as altering nucleosome composition. These chromatin …
disassembling nucleosomes, as well as altering nucleosome composition. These chromatin …
Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure
Chromatin remodellers are helicase-like, ATP-dependent enzymes that alter chromatin
structure and nucleosome positions to allow regulatory proteins access to DNA. Here we …
structure and nucleosome positions to allow regulatory proteins access to DNA. Here we …
Mechanisms of ATP-dependent chromatin remodeling motors
Chromatin remodeling motors play essential roles in all DNA-based processes. These
motors catalyze diverse outcomes ranging from sliding the smallest units of chromatin …
motors catalyze diverse outcomes ranging from sliding the smallest units of chromatin …
Nucleosome sliding mechanisms: new twists in a looped history
F Mueller-Planitz, H Klinker, PB Becker - Nature structural & molecular …, 2013 - nature.com
Nucleosomes, the basic organizational units of chromatin, package and regulate eukaryotic
genomes. ATP-dependent nucleosome-remodeling factors endow chromatin with structural …
genomes. ATP-dependent nucleosome-remodeling factors endow chromatin with structural …
[PDF][PDF] Loss of Snf5 induces formation of an aberrant SWI/SNF complex
The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and
aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 …
aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 …
In silico evidence for sequence-dependent nucleosome sliding
J Lequieu, DC Schwartz… - Proceedings of the …, 2017 - National Acad Sciences
Nucleosomes represent the basic building block of chromatin and provide an important
mechanism by which cellular processes are controlled. The locations of nucleosomes …
mechanism by which cellular processes are controlled. The locations of nucleosomes …
The ATPase domain of ISWI is an autonomous nucleosome remodeling machine
F Mueller-Planitz, H Klinker, J Ludwigsen… - Nature structural & …, 2013 - nature.com
ISWI slides nucleosomes along DNA, enabling the structural changes of chromatin required
for the regulated use of eukaryotic genomes. Prominent mechanistic models imply …
for the regulated use of eukaryotic genomes. Prominent mechanistic models imply …