Artificial intelligence-assisted selection and efficacy prediction of antineoplastic strategies for precision cancer therapy

ZHE Zhang, X Wei - Seminars in Cancer Biology, 2023 - Elsevier
The rapid development of artificial intelligence (AI) technologies in the context of the vast
amount of collectable data obtained from high-throughput sequencing has led to an …

High-throughput genomics and clinical outcome in hard-to-treat advanced cancers: results of the MOSCATO 01 trial

C Massard, S Michiels, C Ferté, MC Le Deley, L Lacroix… - Cancer discovery, 2017 - AACR
High-throughput genomic analyses may improve outcomes in patients with advanced
cancers. MOSCATO 01 is a prospective clinical trial evaluating the clinical benefit of this …

Added value of whole-exome and transcriptome sequencing for clinical molecular screenings of advanced cancer patients with solid tumors

F Koeppel, A Bobard, C Lefebvre, M Pedrero… - The Cancer …, 2018 - journals.lww.com
Comprehensive genomic profiling using high-throughput sequencing brings a wealth of
information, and its place in the clinical setting has been increasingly prominent. This review …

[HTML][HTML] Relevance of a molecular tumour board (MTB) for patients' enrolment in clinical trials: experience of the Institut Curie

C Basse, C Morel, M Alt, MP Sablin, C Franck… - ESMO open, 2018 - Elsevier
Background High throughput molecular screening techniques allow the identification of
multiple molecular alterations, some of which are actionable and can be targeted by …

[HTML][HTML] Impact of molecular tumour board discussion on targeted therapy allocation in advanced prostate cancer

PHJ Slootbeek, ISH Kloots, M Smits… - British Journal of …, 2022 - nature.com
Background Molecular tumour boards (MTB) optimally match oncological therapies to
patients with genetic aberrations. Prostate cancer (PCa) is underrepresented in these MTB …

[HTML][HTML] Does smoking alter the mutation profile of human papillomavirus–driven head and neck cancers?

H Mirghani, L Lacroix, C Rossoni, R Sun… - European Journal of …, 2018 - Elsevier
Background Human papillomavirus (HPV)-driven oropharyngeal cancer (OPC) patients are
characterised by a better prognosis than their HPV-negative counterparts. However, this …

[HTML][HTML] The cost of molecular-guided therapy in oncology: a prospective cost study alongside the MOSCATO trial

A Pagès, S Foulon, Z Zou, L Lacroix, F Lemare… - Genetics in …, 2017 - Elsevier
Aim There is increasing use of molecular technologies to guide cancer treatments, but few
cost data are available. Our objective was to assess the costs of molecular-guided therapy …

Whole exome sequencing in molecular diagnostics of cancer decreases over time: evidence from a cost analysis in the French setting

A Bayle, N Droin, B Besse, Z Zou, Y Boursin… - The European Journal of …, 2021 - Springer
Objectives Although high-throughput sequencing is revolutionising medicine, data on the
actual cost of whole exome sequencing (WES) applications are needed. We aimed at …

Quelle vision des biomarqueurs en 2017? Promesses et défis de la médecine personnalisée en oncologie

R Flippot, C Massard, E Auclin, D Azria, H Bourien… - Bulletin du …, 2017 - Elsevier
Résumé L'utilisation de biomarqueurs en oncologie permet de sélectionner des populations
pouvant bénéficier de traitements anticancéreux plus efficaces et moins toxiques, et …

Impact of a Molecular Sequencing Systematic at Diagnosis in Digestive Oncology: Experience of a French Center

B de Rauglaudre, E Norguet-Monnereau… - Clinical Oncology …, 2021 - inserm.hal.science
Introduction: Tumor-based molecular profiling has increased in the area of precision
medicine. Their routine use is still limited by accessibility, cost and availability of tumor …