[HTML][HTML] N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential

Y Sun, D Jin, Z Zhang, H Ji, X An, Y Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract The N6-methyladenosine (m6A) modification is regulated by methylases, commonly
referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and …

Emerging role of epitranscriptomics in diabetes mellitus and its complications

X Geng, Z Li, Y Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetes mellitus (DM) and its related complications are among the leading causes of
disability and mortality worldwide. Substantial studies have explored epigenetic regulation …

Milk exosomal microRNAs: postnatal promoters of β cell proliferation but potential inducers of β cell de-differentiation in adult life

BC Melnik, G Schmitz - International Journal of Molecular Sciences, 2022 - mdpi.com
Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …

The role of m6A and m6Am RNA modifications in the pathogenesis of diabetes mellitus

D Benak, S Benakova, L Plecita-Hlavata… - Frontiers in …, 2023 - frontiersin.org
The rapidly developing research field of epitranscriptomics has recently emerged into the
spotlight of researchers due to its vast regulatory effects on gene expression and thereby …

The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression

B Yan, X Li, M Peng, Y Zuo, Y Wang, P Liu… - … & Molecular Medicine, 2023 - nature.com
Aberrant glucose metabolism is a characteristic of bladder cancer. Hyperglycemia
contributes to the development and progression of bladder cancer. However, the underlying …

Reduction of mRNA m6A associates with glucose metabolism via YTHDC1 in human and mice

K Yang, J Sun, Z Zhang, M Xiao, D Ren… - Diabetes research and …, 2023 - Elsevier
Abstract Aims N 6-methyladenosine (m 6 A) in mRNA is involved in glucose metabolism. Our
goal is to investigate the relationship of glucose metabolism, m 6 A and YTH domain …

Insights into RNA N6-methyladenosine in Glucose and Lipid Metabolic Diseases and Their Therapeutic Strategies

Y Wu, Y Zeng, Y Ren, J Yu, Q Zhang, X Xiao - Endocrinology, 2024 - academic.oup.com
The incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity,
metabolic syndrome, and nonalcoholic fatty liver disease, is rising, which places an …

[HTML][HTML] m 6A methylation in cellular senescence of age-associated diseases: m 6A methylation in cellular senescence of age-associated diseases

P Gao, F Yao, J Pang, K Yin, X Zhu - Acta Biochimica et Biophysica …, 2023 - ncbi.nlm.nih.gov
Cellular senescence is a state of irreversible cellular growth arrest that occurs in response to
various stresses. In addition to exiting the cell cycle, senescent cells undergo many …

[PDF][PDF] Milk exosomal microRNAs: friend or foe?—a narrative review

BC Melnik, R Weiskirchen, G Schmitz - ExRNA, 2022 - cdn.amegroups.cn
Methods: English literature published between 1990 and 2022 were searched using the
PubMed database focusing on publications including human and bovine MEX, milk …

The epigenetic regulation of RNA N6-methyladenosine methylation in glycolipid metabolism

H Yang, Y Li, L Huang, M Fang, S Xu - Biomolecules, 2023 - mdpi.com
The highly conserved and dynamically reversible N6-methyladenine (m6A) modification has
emerged as a critical gene expression regulator by affecting RNA splicing, translation …