Transient receptor potential (TRP) channels
A Samanta, TET Hughes… - … complexes: Structure and …, 2018 - Springer
Abstract Transient Receptor Potential (TRP) channels are evolutionarily conserved integral
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …
Mechanosensitive ion channels: structural features relevant to mechanotransduction mechanisms
P Jin, LY Jan, YN Jan - Annual review of neuroscience, 2020 - annualreviews.org
Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …
physiological processes that require sensation of mechanical force. Different …
Atomic structure of the open SARS-CoV-2 E viroporin
The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …
[HTML][HTML] Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its
receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin …
receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin …
[HTML][HTML] Molecular physiology of TRPV channels: controversies and future challenges
T Rosenbaum, LD Islas - Annual Review of Physiology, 2023 - annualreviews.org
The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …
molecules that allow the detection of such signals include ion channels, which are proteins …
[HTML][HTML] A structural overview of the ion channels of the TRPM family
The TRPM (transient receptor potential melastatin) family belongs to the superfamily of TRP
cation channels. The TRPM subfamily is composed of eight members that are involved in …
cation channels. The TRPM subfamily is composed of eight members that are involved in …
[HTML][HTML] The structure of the polycystic kidney disease channel PKD2 in lipid nanodiscs
Summary The Polycystic Kidney Disease 2 (Pkd2) gene is mutated in autosomal dominant
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms
Z Deng, N Paknejad, G Maksaev… - Nature structural & …, 2018 - nature.com
The transient receptor potential (TRP) channel TRPV4 participates in multiple biological
processes, and numerous TRPV4 mutations underlie several distinct and devastating …
processes, and numerous TRPV4 mutations underlie several distinct and devastating …
Structure and gating mechanism of the transient receptor potential channel TRPV3
AK Singh, LL McGoldrick, AI Sobolevsky - Nature structural & molecular …, 2018 - nature.com
Transient receptor potential vanilloid subfamily member 3 (TRPV3) channel plays a crucial
role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with …
role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with …
Electron cryo-microscopy structure of the mechanotransduction channel NOMPC
Mechanosensory transduction for senses such as proprioception, touch, balance,
acceleration, hearing and pain relies on mechanotransduction channels, which convert …
acceleration, hearing and pain relies on mechanotransduction channels, which convert …