Simple Summary Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment
of blood cancers. However, their effectiveness meets challenges in solid tumors …

Adoptive T cellular immunotherapies have emerged as relevant approaches for treating
cancer patients who have relapsed or become refractory (R/R) to traditional cancer …

Major challenges of chimeric antigen receptor (CAR)-T cell therapy include poor antigen
sensitivity and cell persistence. Here, we report a solution to these issues by exploiting CAR …

Chimeric antigen receptor (CAR) T cells have become an established form of
immunotherapy and continue to show promising results for the treatment of hematological …

Chimeric antigen receptor (CAR) T cells have transformed the landscape of cancer therapy
and demonstrate unprecedented success in treating relapsed/refractory blood cancers. The …

Immune cell signaling is initiated at complex intercellular junctions or through multivalent
interactions with ligands. Sites of immune receptor triggering are regulated by lipid …

Chimeric Antigen receptor T cell (CAR-T) treatments for solid cancers have been
compromised by limited expansion and survival in the tumor microenvironment following …

The integration of mechanical forces with cellular behavior represents a fundamental
mechanism in immune system function 1. Mechanical force plays essential roles in …