This article reviews the current knowledge and recent advancements in computational
modeling of the cell cycle. It offers a comparative analysis of various modeling paradigms …

Cells vary in volume throughout their life cycle and in many other circumstances, while their
genome remains identical. Hence, the RNA production factory must adapt to changing …

Cells employ control strategies to maintain a stable size. Dividing at a target size (the “sizer”
strategy) is thought to produce the tightest size distribution. However, this result follows from …

The rate at which individual bacterial cells grow depends on the concentrations of cellular
components such as ribosomes and proteins. These concentrations continuously fluctuate …

Stress defense and cell growth are inversely related in bulk culture analyses; however,
these studies miss substantial cell-to-cell heterogeneity, thus obscuring true phenotypic …

Single-cell experiments revealed substantial variability in generation times, growth rates but
also in birth and division sizes between genetically identical cells. Understanding how these …

It has been recently shown that the exponential growth rate of a population of bacterial cells
starting from a single cell shows transient oscillations due to early synchronized bursts of …

The Luria-Delbr\" uck model is a classic model of population dynamics with random
mutations, that has been used historically to prove that random mutations drive evolution. In …

Many organisms maintain generalized stress responses activated by adverse conditions.
Although details vary, a common theme is the redirection of transcriptional and translational …

Single-cells grow by increasing their biomass and size. Here, we report that while mass and
size accumulation rates of single Escherichia coli cells are exponential, their density and …