Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many
ways, from altering the activity of antioxidant enzymes to the level of transcription factors …

Autophagy contributes to the maintenance of intracellular homeostasis in most cells of
cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …

Long noncoding RNAs (lncRNA) have been associated with various types of cancer;
however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we …