RNA structural dynamics as captured by molecular simulations: a comprehensive overview
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
Nucleases: diversity of structure, function and mechanism
W Yang - Quarterly reviews of biophysics, 2011 - cambridge.org
Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
Self‐processing of ribozyme‐flanked RNAs into guide RNAs in vitro and in vivo for CRISPR‐mediated genome editing
Y Gao, Y Zhao - Journal of integrative plant biology, 2014 - Wiley Online Library
CRISPR/Cas9 uses a guide RNA (gRNA) molecule to execute sequence‐specific DNA
cleavage and it has been widely used for genome editing in many organisms. Modifications …
cleavage and it has been widely used for genome editing in many organisms. Modifications …
Understanding nucleic acid–ion interactions
Ions surround nucleic acids in what is referred to as an ion atmosphere. As a result, the
folding and dynamics of RNA and DNA and their complexes with proteins and with each …
folding and dynamics of RNA and DNA and their complexes with proteins and with each …
The chemical repertoire of natural ribozymes
Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules,
called ribozymes, have intrinsic enzyme-like activity—they can catalyse chemical reactions …
called ribozymes, have intrinsic enzyme-like activity—they can catalyse chemical reactions …
Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms
The technique of small-probe contact dot surfaces is described as a method for calculating
and displaying the detailed atomic contacts inside or between molecules. It allows one both …
and displaying the detailed atomic contacts inside or between molecules. It allows one both …
Modified oligonucleotides: synthesis and strategy for users
S Verma, F Eckstein - Annual review of biochemistry, 1998 - annualreviews.org
Synthetic oligonucleotide analogs have greatly aided our understanding of several
biochemical processes. Efficient solid-phase and enzyme-assisted synthetic methods and …
biochemical processes. Efficient solid-phase and enzyme-assisted synthetic methods and …
Ribozyme structures and mechanisms
EA Doherty, JA Doudna - Annual review of biochemistry, 2000 - annualreviews.org
▪ Abstract The past few years have seen exciting advances in understanding the structure
and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed …
and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed …
Click nucleic acid ligation: applications in biology and nanotechnology
AH El-Sagheer, T Brown - Accounts of chemical research, 2012 - ACS Publications
Biochemical strategies that use a combination of synthetic oligonucleotides, thermostable
DNA polymerases, and DNA ligases can produce large DNA constructs up to 1 megabase in …
DNA polymerases, and DNA ligases can produce large DNA constructs up to 1 megabase in …
[HTML][HTML] Tertiary contacts distant from the active site prime a ribozyme for catalysis
M Martick, WG Scott - Cell, 2006 - cell.com
Minimal hammerhead ribozymes have been characterized extensively by static and time-
resolved crystallography as well as numerous biochemical analyses, leading to mutually …
resolved crystallography as well as numerous biochemical analyses, leading to mutually …