An overlooked and underrated endemic mycosis—Talaromycosis and the pathogenic fungus Talaromyces marneffei

F Wang, RH Han, S Chen - Clinical Microbiology Reviews, 2023 - Am Soc Microbiol
Talaromycosis is an invasive mycosis endemic in tropical and subtropical Asia and is
caused by the pathogenic fungus Talaromyces marneffei. Approximately 17,300 cases of T …

Fungal dimorphism: the switch from hyphae to yeast is a specialized morphogenetic adaptation allowing colonization of a host

KJ Boyce, A Andrianopoulos - FEMS microbiology reviews, 2015 - academic.oup.com
The ability of pathogenic fungi to switch between a multicellular hyphal and unicellular yeast
growth form is a tightly regulated process known as dimorphic switching. Dimorphic …

Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

K Pruksaphon, JD Nosanchuk, K Ratanabanangkoon… - Journal of Fungi, 2022 - mdpi.com
Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimorphic
fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic …

Thermally dimorphic human fungal pathogens—polyphyletic pathogens with a convergent pathogenicity trait

A Sil, A Andrianopoulos - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Fungi are adept at changing their cell shape and developmental program in response to
signals in their surroundings. Here we focus on a group of evolutionarily related fungal …

Targeted gene insertion and replacement in the basidiomycete Ganoderma lucidum by inactivation of nonhomologous end joining using CRISPR/Cas9

JL Tu, XY Bai, YL Xu, N Li, JW Xu - Applied and Environmental …, 2021 - Am Soc Microbiol
Targeted gene insertion or replacement is a promising genome-editing tool for molecular
breeding and gene engineering. Although CRISPR/Cas9 works well for gene disruption and …

Construction of an expression platform for fungal secondary metabolite biosynthesis in Penicillium crustosum

J Zhou, X Chen, SM Li - Applied Microbiology and Biotechnology, 2024 - Springer
Filamentous fungi are prolific producers of bioactive natural products and play a vital role in
drug discovery. Yet, their potential cannot be fully exploited since many biosynthetic genes …

Conversion of viridicatic acid to crustosic acid by cytochrome P450 enzyme-catalysed hydroxylation and spontaneous cyclisation

J Zhou, SM Li - Applied Microbiology and Biotechnology, 2021 - Springer
Cytochrome P450 monooxygenases (P450s) are considered nature's most versatile
catalysts and play a crucial role in regio-and stereoselective oxidation reactions on a broad …

Intracellular Growth Is Dependent on Tyrosine Catabolism in the Dimorphic Fungal Pathogen Penicillium marneffei

KJ Boyce, A McLauchlan, L Schreider… - PLoS …, 2015 - journals.plos.org
During infection, pathogens must utilise the available nutrient sources in order to grow while
simultaneously evading or tolerating the host's defence systems. Amino acids are an …

Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites

YM Qiao, RL Yu, P Zhu - RSC advances, 2019 - pubs.rsc.org
The revolutionary discovery of penicillin only marks the start of our exploration for valuable
fungal natural products. Advanced genome sequencing technologies have translated the …

Increasing the homologous recombination efficiency of eukaryotic microorganisms for enhanced genome engineering

Y Ding, KF Wang, WJ Wang, YR Ma, TQ Shi… - Applied microbiology …, 2019 - Springer
In recent years, eukaryotic microorganisms have been widely applied to offer many solutions
for everyday life and have come to play important roles in agriculture, food, health care, and …