Heat as a stressor of poultry has been studied extensively for many decades; it affects
poultry production on a worldwide basis and has significant impact on well-being and …

Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

The aryl-hydrocarbon receptor (AHR) is a ligand-activated transcription factor that buoys
intestinal immune responses. AHR induces its own negative regulator, the AHR repressor …

We first proposed the mitochondrial cascade hypothesis of sporadic Alzheimer's disease
(AD) in 2004. Our core assumptions were a person's genes determine baseline …

Viable Alzheimer's disease (AD) hypotheses must account for its age-dependence;
commonality; association with amyloid precursor protein, tau, and apolipoprotein E biology; …

Oxidative stress (OS) has been demonstrated to be involved in the pathogenesis of the two
major types of dementia: Alzheimer's disease (AD) and vascular dementia (VaD). Evidence …

Agonists of the peroxisome proliferator activated receptor gamma (PPARγ) are currently
used for treatment of type 2 diabetes due to their insulin sensitizing and glucose metabolism …

Oxidative stress and inflammation are implicated in neurodegenerative diseases including
Parkinson's disease (PD) and Huntington's disease (HD). Celastrol is a potent anti …

Apoptosis is implicated in neonatal hypoxic/ischemic (H/I) brain injury among various forms
of cell death. Here we investigate whether overexpression of heat shock protein (Hsp) 70, an …

The heat shock response (HSR) is a conserved cellular defensive response against stresses
such as temperature, oxidative stress and heavy metals. A significant group of players in the …