Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies
available to treat stroke are very limited. There is an urgent need to develop novel …

A bulk of experimental evidence supports the idea that the stroke-damaged adult brain
makes an attempt to repair itself by producing new neurons also in areas where …

The establishment of neuronal and glial networks in the brain depends on the activities of
neural progenitors, which are influenced by cell-intrinsic mechanisms, interactions with the …

Lifelong neurogenesis and incorporation of newborn neurons into mature neuronal circuits
operates in specialized niches of the mammalian brain and serves as role model for …

Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …

Caspases are intimately associated with altering various signaling pathways, resulting in
programmed cell death or apoptosis. Apoptosis is necessary for the normal homeostasis of …

Neural stem/precursor cells in the adult brain reside in the subventricular zone (SVZ) of the
lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus …

Stroke remains the number one cause of morbidity in the United States. Within weeks to
months after an ischemic event, there is a resolution of inflammation and evidence of …