Chromatin's physical properties shape the nucleus and its functions
The cell nucleus encloses, organizes, and protects the genome. Chromatin maintains
nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton …
nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton …
Soft materials as biological and artificial membranes
The past few decades have seen emerging growth in the field of soft materials for synthetic
biology. This review focuses on soft materials involved in biological and artificial …
biology. This review focuses on soft materials involved in biological and artificial …
The nucleus acts as a ruler tailoring cell responses to spatial constraints
INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor …
when the regulation of cell growth and proliferation fails during the formation of a tumor …
Lipid droplets are intracellular mechanical stressors that impair hepatocyte function
Matrix stiffening and external mechanical stress have been linked to disease and cancer
development in multiple tissues, including the liver, where cirrhosis (which increases …
development in multiple tissues, including the liver, where cirrhosis (which increases …
Surface fluctuations and coalescence of nucleolar droplets in the human cell nucleus
The nucleolus is a membraneless organelle embedded in chromatin solution inside the cell
nucleus. By analyzing surface dynamics and fusion kinetics of human nucleoli in vivo, we …
nucleus. By analyzing surface dynamics and fusion kinetics of human nucleoli in vivo, we …
[HTML][HTML] Nuclear lamins: Structure and function in mechanobiology
Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …
Nucleolar dynamics and interactions with nucleoplasm in living cells
Liquid-liquid phase separation (LLPS) has been recognized as one of the key cellular
organizing principles and was shown to be responsible for formation of membrane-less …
organizing principles and was shown to be responsible for formation of membrane-less …
Nuclear envelope deformation controls cell cycle progression in response to mechanical force
J Aureille, V Buffière‐Ribot, BE Harvey, C Boyault… - EMBO …, 2019 - embopress.org
The shape of the cell nucleus can vary considerably during developmental and pathological
processes; however, the impact of nuclear morphology on cell behavior is not known. Here …
processes; however, the impact of nuclear morphology on cell behavior is not known. Here …
Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in …
CM Hobson, M Kern, ET O'Brien III… - Molecular biology of …, 2020 - Am Soc Cell Biol
Nuclei are often under external stress, be it during migration through tight constrictions or
compressive pressure by the actin cap, and the mechanical properties of nuclei govern their …
compressive pressure by the actin cap, and the mechanical properties of nuclei govern their …
Super-resolved 3D tracking of cargo transport through nuclear pore complexes
Nuclear pore complexes (NPCs) embedded within the nuclear envelope mediate rapid,
selective and bidirectional traffic between the cytoplasm and the nucleoplasm. Deciphering …
selective and bidirectional traffic between the cytoplasm and the nucleoplasm. Deciphering …