Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

CO Vrancianu, I Gheorghe, IB Czobor, MC Chifiriuc - Microorganisms, 2020 - mdpi.com
Antibiotic resistance is one of the biggest challenges for the clinical sector and industry,
environment and societal development. One of the most important pathogens responsible …

[HTML][HTML] A rulebook for peptide control of legume–microbe endosymbioses

S Roy, LM Müller - Trends in plant science, 2022 - cell.com
Plants engage in mutually beneficial relationships with microbes, such as arbuscular
mycorrhizal fungi or nitrogen-fixing rhizobia, for optimized nutrient acquisition. In return, the …

Evaluation of the Antimicrobial Activity in Host-Mimicking Media and In Vivo Toxicity of Antimicrobial Polymers as Functional Mimics of AMPs

R Garcia Maset, A Hapeshi, S Hall… - … Applied Materials & …, 2022 - ACS Publications
Activity tests for synthetic antimicrobial compounds are often limited to the minimal inhibitory
concentration assay using standard media and bacterial strains. In this study, a family of …

Mastoparans: a group of multifunctional α-helical peptides with promising therapeutic properties

CJC de Santana, OR Pires Júnior, W Fontes… - Frontiers in Molecular …, 2022 - frontiersin.org
Biologically active peptides have been attracting increasing attention, whether to improve
the understanding of their mechanisms of action or in the search for new therapeutic drugs …

An Update on the Therapeutic Potential of Antimicrobial Peptides against Acinetobacter baumannii Infections

K Rangel, GC Lechuga, DW Provance Jr, CM Morel… - Pharmaceuticals, 2023 - mdpi.com
The rise in antibiotic-resistant strains of clinically important pathogens is a major threat to
global health. The World Health Organization (WHO) has recognized the urgent need to …

Peptides as a therapeutic strategy against Klebsiella pneumoniae

CM de Souza, ÁP da Silva, NGO Júnior… - Trends in …, 2022 - cell.com
Increasing levels of resistance to conventional antibiotics have led to a search for new
therapeutic options against bacterial infections. Klebsiella pneumoniae is considered a …

AtGCS promoter-driven clustered regularly interspaced short palindromic repeats/Cas9 highly efficiently generates homozygous/biallelic mutations in the transformed …

S Liu, X Wang, Q Li, W Peng, Z Zhang, P Chu… - Frontiers in Plant …, 2022 - frontiersin.org
Agrobacterium rhizogenes–mediated (ARM) transformation is an efficient and powerful tool
to generate transgenic roots to study root-related biology. For loss-of-function studies …

Legume plant peptides as sources of novel antimicrobial molecules against human pathogens

RM Lima, BB Rathod, H Tiricz, DHO Howan… - Frontiers in Molecular …, 2022 - frontiersin.org
Antimicrobial peptides are prominent components of the plant immune system acting against
a wide variety of pathogens. Legume plants from the inverted repeat lacking clade (IRLC) …

Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. aureus and P. aeruginosa biofilms

RG Maset, A Hapeshi, J Lapage, N Harrington… - npj Biofilms and …, 2023 - nature.com
Biofilm infections are associated with a high mortality risk for patients. Antibiotics perform
poorly against biofilm communities, so high doses and prolonged treatments are often used …

Unexplored arsenals of legume peptides with potential for their applications in medicine and agriculture

RM Lima, S Kylarová, P Mergaert… - Frontiers in …, 2020 - frontiersin.org
During endosymbiosis, bacteria live intracellularly in the symbiotic organ of their host. The
host controls the proliferation of endosymbionts and prevents their spread to other tissues …