Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

Membrane scaffold protein nanodiscs (MSPNDs) are an invaluable tool for improving
purified membrane protein (MP) stability and activity compared to traditional micellar …

Understanding the higher-order structure of membrane proteins (MPs), which are vital for
numerous biological processes, is crucial for comprehending their function. Although …

Daptomycin is a cyclic lipopeptide antibiotic that targets the lipid membrane of Gram-positive
bacteria. Membrane fluidity and charge can affect daptomycin activity, but its mechanisms …

Conspectus Protein higher-order structure (HOS) is key to biological function because the
mechanisms of protein machinery are encoded in protein three-dimensional structures …

Protein footprinting mass spectrometry (MS), an emerging approach to elucidate higher-
order structure (HOS) and binding, benefits from the iterative development of reaction …

Antimicrobial peptides (AMPs) are an important part of the innate immune system and
demonstrate promising applications in the fight against antibiotic-resistant infections due to …

Structural biology is entering an exciting time where many new high‐resolution structures of
large complexes and membrane proteins (MPs) are determined regularly. These advances …

Integral membrane proteins (IMPs) perform a range of diverse functions and their
dysfunction underlies numerous pathological conditions. Consequently, IMPs constitute …

Protein footprinting mass spectrometry (MS), an emerging approach to elucidate higher
order structure (HOS) and binding, benefits from the iterative development of reaction …