Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …

Self-maintaining resident macrophages populate all mammalian organs. In addition to their
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …

Macrophages are typically identified as classically activated (M1) macrophages and
alternatively activated (M2) macrophages, which respectively exhibit pro-and anti …

Macrophages and conventional dendritic cells (cDCs) are distributed throughout the body,
maintaining tissue homeostasis and tolerance to self and orchestrating innate and adaptive …

Maintaining the correct number of healthy red blood cells (RBCs) is critical for proper
oxygenation of tissues throughout the body. Therefore, RBC homeostasis is a tightly …

Located within red pulp cords, splenic red pulp macrophages (RPMs) are constantly
exposed to the blood flow, clearing senescent red blood cells (RBCs) and recycling iron …

Immunity to malaria is often considered slow to develop but this only applies to defense
mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe …

Monocytes are innate immune cells essential for host protection against malaria. Upon
activation, monocytes function to help reduce parasite burden through phagocytosis …