Role of cholinergic signaling in Alzheimer's disease
ZR Chen, JB Huang, SL Yang, FF Hong - Molecules, 2022 - mdpi.com
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …
The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers
K San Tang - Life sciences, 2019 - Elsevier
Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and
cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model …
cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model …
Role of p38/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy
A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …
Design, synthesis, and pharmacological evaluation of embelin–aryl/alkyl amine hybrids as orally bioavailable blood–brain barrier permeable multitargeted agents with …
VK Nuthakki, S Choudhary, CN Reddy… - ACS chemical …, 2023 - ACS Publications
The complex and multifaceted nature of Alzheimer's disease has brought about a pressing
demand to develop ligands targeting multiple pathways to combat its outrageous …
demand to develop ligands targeting multiple pathways to combat its outrageous …
Production of Prunin and Naringenin by Using Naringinase from Aspergillus oryzae NYO-2 and Their Neuroprotective Properties and Debitterization
HJ Seong, AE Im, H Kim, N Park, KY Yang… - Journal of Agricultural …, 2023 - ACS Publications
Naringin is a flavanone glycoside in citrus fruits that has various biological functions.
However, its bitterness affects the quality, economic value, and consumer acceptability of …
However, its bitterness affects the quality, economic value, and consumer acceptability of …
A systematic review for the development of Alzheimer's disease in in vitro models: a focus on different inducing agents
M Prajapat, G Kaur, G Choudhary, P Pahwa… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and
is associated with dementia. Presently, various chemical and environmental agents are …
is associated with dementia. Presently, various chemical and environmental agents are …
Neuroprotective effects of total alkaloids fraction of Huperzia serrata on scopolamine‐induced neurodegenerative animals
Huperzia serrata contains Huperzine A (HupA)—an alkaloid used to treat cognitive
dysfunction. In this study, we used the total alkaloids (HsAE) to investigate their potential in …
dysfunction. In this study, we used the total alkaloids (HsAE) to investigate their potential in …
Enhancement of debitterness, water-solubility, and neuroprotective effects of naringin by transglucosylation
AE Im, S Eom, HJ Seong, H Kim, JY Cho, D Kim… - Applied Microbiology …, 2023 - Springer
Naringin found in citrus fruits is a flavanone glycoside with numerous biological activities.
However, the bitterness, low water-solubility, and low bioavailability of naringin are the main …
However, the bitterness, low water-solubility, and low bioavailability of naringin are the main …
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
L Tancheva, R Kalfin, B Minchev, D Uzunova… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease manifests as a complex pathological condition, with neuroinflammation,
oxidative stress and cholinergic dysfunction being a few of the many pathological changes …
oxidative stress and cholinergic dysfunction being a few of the many pathological changes …
Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile
Alzheimer's disease (AD) is a chronic disease that is multifactorial. Its underlying cause and
mechanisms are yet to be fully understood and numerous research are underway to develop …
mechanisms are yet to be fully understood and numerous research are underway to develop …