Cancer stem cells-emanated therapy resistance: implications for liposomal drug delivery systems

H Dianat-Moghadam, M Heidarifard… - Journal of controlled …, 2018 - Elsevier
It is verified that failure in cancer therapy by conventional chemotherapeutic agents arise
from cancer heterogeneity. That, a small subpopulation of cancer cells known as “cancer …

Immersed-finite-element method for deformable particle suspensions in viscous and viscoelastic media

A Saadat, CJ Guido, G Iaccarino, ESG Shaqfeh - Physical Review E, 2018 - APS
Deformable elastic bodies in viscous and viscoelastic media constitute a large portion of
synthetic and biological complex fluids. We present a parallelized three-dimensional …

Numerical simulation of magnetic nanoparticle-based drug delivery in presence of atherosclerotic plaques and under the effects of magnetic field

M Varmazyar, MR Habibi, M Amini, AH Pordanjani… - Powder Technology, 2020 - Elsevier
The effect of stenosis on magnetonanoparticles (MNPs) distribution within the lumen is
presented in pulsatile blood flow in the presence of a non-uniform magnetic field. The effects …

Hydrodynamics simulation of red blood cells: Employing a penalty method with double jump composition of lower order time integrator

A Laadhari, A Deeb, B Kaoui - Mathematical Methods in the …, 2023 - Wiley Online Library
We propose a numerical framework tailored for simulating the dynamics of vesicles with
inextensible membranes, which mimic red blood cells, immersed in a non‐Newtonian fluid …

Computational modeling of individual red blood cell dynamics using discrete flow composition and adaptive time-stepping strategies

A Laadhari, A Deeb - Symmetry, 2023 - mdpi.com
In this article, we present a finite element method for studying the dynamic behavior of
deformable vesicles, which mimic red blood cells, in a non-Newtonian Casson fluid. The …

Lattice Boltzmann simulation of advection-diffusion of chemicals and applications to blood flow

H Zhang, C Misbah - Computers & Fluids, 2019 - Elsevier
Diffusion of solutes is often encountered in many biological processes. In the blood micro
circulation system, solutes, such as oxygen and calcium molecules, as well as Adenosine …

Interplay between size and softness in the vascular dynamics of microcarriers

W Chien, DA Fedosov, P Decuzzi - Physics of Fluids, 2023 - pubs.aip.org
The geometry and mechanical properties of blood-borne particles play a major role in
determining their vascular behavior and ability to evade immune cell sequestration. Within …

Current perspectives and trend of computer-aided drug design: a review and bibliometric analysis

Z Wu, S Chen, Y Wang, F Li, H Xu, M Li… - … Journal of Surgery, 2024 - journals.lww.com
Aim: Computer-aided drug design (CADD) is a drug design technique for computing ligand–
receptor interactions and is involved in various stages of drug development. To better grasp …

Solute release from an elastic capsule flowing through a microfluidic channel constriction

ZY Luo, BF Bai - Physics of Fluids, 2019 - pubs.aip.org
In recent years, microfluidic channels with narrow constrictions are extensively proposed as
a new but excellent possibility for advanced delivery technologies based on either natural or …

Asymmetric Stokes flow induced by a transverse point force acting near a finite-sized elastic membrane

A Daddi-Moussa-Ider - Journal of the Physical Society of Japan, 2020 - journals.jps.jp
A deep understanding of the physical interactions between nanoparticles and target cell
membranes is important in designing efficient nanocarrier systems for drug delivery …