The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Arrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR)
desensitization, signaling, and internalization. The arrestin family consists of four subtypes …

The risk of developing Alzheimer's disease is mediated by a combination of genetics and
environmental factors, such as stress, sleep abnormalities and traumatic brain injury …

Abstract Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a
mitochondrial protein that plays important roles in cristae structure, oxidative …

APOE ε4 is the major genetic risk factor for sporadic Alzheimer's disease (AD). Although
APOE ε4 is known to promote Aβ pathology, recent data also support an effect of APOE …

Signals from G-protein-coupled receptors (GPCRs) are the most frequently targeted
pathways of currently prescribed therapeutics. Rather than being a simple switch, it is now …

β-arrestins, which have multiple cellular functions, were initially described as proteins that
desensitize rhodopsin and other G protein-coupled receptors. The cytoskeletal system plays …

G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of
mammalian transmembrane proteins. These receptors are involved in a wide range of …

Hippocampal-dependent memory abilities including spatial memory decline with age.
Exercise improves memory decline in aging brain, but, the precise mechanisms are still …