The failure of proteins to penetrate mammalian cells or target tumor cells restricts their value
as therapeutic tools in a variety of diseases such as cancers. Recently, protein transduction …

The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Cell-penetrating peptides (CPPs) have been studied for their capacity to translocate across
the lipid membrane of several cell types. In membrane translocation, these peptides can …

Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is
a powerful technique to study genetic function; however, discrepancies between knockdown …

The plasma membrane remains a major barrier for intracellular drug delivery, to overcome
this issue, a variety of approaches have been developed and used to deliver therapeutic …

Efficient cargo uptake is essential for cell-penetrating peptide (CPP) therapeutics, which
deliver widely diverse cargoes by exploiting natural cell processes to penetrate the cell's …

Precision-cut lung slices (PCLS) are used for a variety of applications. However, methods to
manipulate genes in PCLS are currently limited. We developed a new method, TAT-Cre …

For almost 30 years, studies have confirmed the effectiveness of cell-penetrating peptides
(CPPs) in the facilitation of the intracellular delivery of various cargo molecules, including …

A significant unmet need in treating neurodegenerative disease is effective methods for
delivery of biologic drugs, such as peptides, proteins, or nucleic acids into the central …

Internalization of peptides and proteins into live cells is an essential prerequisite for studies
on intracellular signal pathways, for treatment of certain microbial diseases and for signal …