Detection algorithms and attentive points of safety signal using spontaneous reporting systems as a clinical data source
Y Noguchi, T Tachi, H Teramachi - Briefings in bioinformatics, 2021 - academic.oup.com
Continuous evaluation of drug safety is needed following approval to determine adverse
events (AEs) in patient populations with diverse backgrounds. Spontaneous reporting …
events (AEs) in patient populations with diverse backgrounds. Spontaneous reporting …
A review on bayesian deep learning in healthcare: Applications and challenges
In the last decade, Deep Learning (DL) has revolutionized the use of artificial intelligence,
and it has been deployed in different fields of healthcare applications such as image …
and it has been deployed in different fields of healthcare applications such as image …
Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study
Summary Background Immune checkpoint inhibitors (ICIs) have substantially improved
clinical outcomes in multiple cancer types and are increasingly being used in early disease …
clinical outcomes in multiple cancer types and are increasingly being used in early disease …
Big data for cyber physical systems in industry 4.0: a survey
With the technology development in cyber physical systems and big data, there are huge
potential to apply them to achieve personalization and improve resource efficiency in …
potential to apply them to achieve personalization and improve resource efficiency in …
Ibrutinib-mediated atrial fibrillation attributable to inhibition of C-terminal Src kinase
Background: Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-
cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly …
cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly …
Cardiovascular adverse events reported from COVID-19 vaccines: a study based on WHO database
R Jeet Kaur, S Dutta, J Charan… - … journal of general …, 2021 - Taylor & Francis
Background Thirteen COVID-19 vaccines are granted emergency approval. It is crucial to
monitor their adverse events post vaccination. The present study focuses on cardiovascular …
monitor their adverse events post vaccination. The present study focuses on cardiovascular …
Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study
DB Johnson, A Manouchehri, AM Haugh… - … for immunotherapy of …, 2019 - Springer
Background Immune checkpoint inhibitors (ICI) produce durable antitumor responses but
provoke autoimmune toxicities, including uncommon but potentially devastating neurologic …
provoke autoimmune toxicities, including uncommon but potentially devastating neurologic …
Cardiovascular toxicities associated with ibrutinib
JE Salem, A Manouchehri, M Bretagne… - Journal of the American …, 2019 - jacc.org
Background: Ibrutinib has revolutionized treatment for several B-cell malignancies.
However, a recent clinical trial where ibrutinib was used in a front-line setting showed …
However, a recent clinical trial where ibrutinib was used in a front-line setting showed …
Association of facial paralysis with mRNA COVID-19 vaccines: a disproportionality analysis using the World Health Organization pharmacovigilance database
Methods| Disproportionality analyses are hypothesisgenerating methods that aim to detect
putative associations between drugs and adverse drug reactions. Such methods quantify the …
putative associations between drugs and adverse drug reactions. Such methods quantify the …
Association between different GLP-1 receptor agonists and gastrointestinal adverse reactions: a real-world disproportionality study based on FDA adverse event …
L Liu, J Chen, L Wang, C Chen, L Chen - Frontiers in Endocrinology, 2022 - frontiersin.org
Objective Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have significantly
improved clinical effects on glycemic control. However, real-world data concerning the …
improved clinical effects on glycemic control. However, real-world data concerning the …