Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International Journal of Molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

N Shrine, AG Izquierdo, J Chen, R Packer, RJ Hall… - Nature …, 2023 - nature.com
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

KF Chung, IM Adcock - European Respiratory Journal, 2008 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease

T Yoshida, RM Tuder - Physiological reviews, 2007 - journals.physiology.org
Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

[HTML][HTML] FGF/FGFR signaling: From lung development to respiratory diseases

L Yang, F Zhou, D Zheng, D Wang, X Li, C Zhao… - Cytokine & Growth …, 2021 - Elsevier
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …

Cytokine inhibition in the treatment of COPD

G Caramori, IM Adcock, A Di Stefano… - International journal of …, 2014 - Taylor & Francis
Cytokines play an important part in many pathobiological processes of chronic obstructive
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …

[PDF][PDF] TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2/ERK pathway

L Xiao, Y Du, Y Shen, Y He, H Zhao… - Front Biosci (Landmark …, 2012 - article.imrpress.com
Introduction 3. Materials and methods 3.1. Type II Cell Culture 3.2. FGF-2 detection 3.3.
Immunofluorescence 3.4. Cell proliferation assay 3.5. Cell cycle analysis by fluorescence …

Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells

L Marek, KE Ware, A Fritzsche, P Hercule… - Molecular …, 2009 - ASPET
Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and
EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase …

COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link

S Bozinovski, R Vlahos, D Anthony… - British journal of …, 2016 - Wiley Online Library
Cigarette smoking has reached epidemic proportions within many regions of the world and
remains the highest risk factor for chronic obstructive pulmonary disease (COPD) and lung …