Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

Although we have amassed extensive catalogues of signalling network components, our
understanding of the spatiotemporal control of emergent network structures has lagged …

Membrane lipids and proteins are non-randomly distributed and are unable to diffuse freely
in the plane of the membrane. This is because of multiple constraints imposed both by the …

Membrane lateral heterogeneity is accepted as a requirement for the function of biological
membranes and the notion of lipid rafts gives specificity to this broad concept. However, the …

Lipid rafts are specialized structures on the plasma membrane that have an altered lipid
composition as well as links to the cytoskeleton. It has been proposed that these structures …

The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …

The hypothesis that lipid rafts exist in plasma membranes and have crucial biological
functions remains controversial. The lateral heterogeneity of proteins in the plasma …

Studies over several decades have documented the beneficial actions of n-3
polyunsaturated fatty acids (PUFAs), which are plentiful in fish oil, in different disease states …

The plasma membrane (PM) serves as the functional interface between a cell and its
environment, hosting extracellular signal transduction and nutrient transport among a variety …