Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …
JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Regulation and role of fungal secondary metabolites
J Macheleidt, DJ Mattern, J Fischer… - Annual review of …, 2016 - annualreviews.org
Fungi have the capability to produce a tremendous number of so-called secondary
metabolites, which possess a multitude of functions, eg, communication signals during …
metabolites, which possess a multitude of functions, eg, communication signals during …
Cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters
CLM Gilchrist, TJ Booth, B van Wersch… - Bioinformatics …, 2021 - academic.oup.com
Motivation Genes involved in coordinated biological pathways, including metabolism, drug
resistance and virulence, are often collocalized as gene clusters. Identifying homologous …
resistance and virulence, are often collocalized as gene clusters. Identifying homologous …
Plant metabolic gene clusters in the multi-omics era
Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …
products. The discovery of operon-like gene clusters in plants has provided a new …
Fungal cordycepin biosynthesis is coupled with the production of the safeguard molecule pentostatin
Cordycepin (COR) and pentostatin (PTN) are adenosine analogs with related bioactivity
profiles as both mimic adenosine and can inhibit some of the processes that are adenosine …
profiles as both mimic adenosine and can inhibit some of the processes that are adenosine …
Traversing the fungal terpenome
MB Quin, CM Flynn, C Schmidt-Dannert - Natural product reports, 2014 - pubs.rsc.org
Covering: 1965–2014 Fungi (Ascomycota and Basidiomycota) are prolific producers of
structurally diverse terpenoid compounds. Classes of terpenoids identified in fungi include …
structurally diverse terpenoid compounds. Classes of terpenoids identified in fungi include …
Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …
Species include those with industrial applications, important pathogens of humans, animals …
The birth, evolution and death of metabolic gene clusters in fungi
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …
involved in ecologically specialized or accessory functions. Genes in these pathways are …