Obesity has become a major public health problem. Given the current increase in life
expectancy, the prevalence of obesity also raises steadily among older age groups. The …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …

Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite
profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are …

Longevity is regulated by a network of closely linked metabolic systems. We used a
combination of mouse population genetics and RNA interference in Caenorhabditis elegans …

Background: p53 is a tumor suppressor protein involved in regulating a wide array of
signaling pathways. The role of p53 in the cell is determined by the type of imposed …

Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe
a luciferase knockin mouse (p16 LUC), which faithfully reports expression of p16 INK4a, a …

Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major
contributor to disability and frailty in the elderly. Previous studies found a protective effect of …

Aging is characterized by a general decline in cellular function, which ultimately will affect
whole body homeostasis. Although DNA damage and oxidative stress all contribute to …

A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related
diseases in laboratory animals is greatly sought after. We and others have shown that …

Motivation: Numerous microarray studies of aging have been conducted, yet given the noisy
nature of gene expression changes with age, elucidating the transcriptional features of …