Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and
exogenous processes, and their negative effects are neutralized by antioxidant defenses …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …

There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …

Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …

As an essential trace element, selenium participates in numerous important life processes
and plays a significant role for human beings. Owning to its unique physical, chemical and …