Connecting chemistry and biology through molecular descriptors

A Fernández-Torras, A Comajuncosa-Creus… - Current Opinion in …, 2022 - Elsevier
Through the representation of small molecule structures as numerical descriptors and the
exploitation of the similarity principle, chemoinformatics has made paramount contributions …

Recent trends in detecting, controlling, and detoxifying of patulin mycotoxin using biotechnology methods

GL Ngolong Ngea, Q Yang, R Castoria… - … Reviews in Food …, 2020 - Wiley Online Library
Patulin (PAT) is a mycotoxin that can contaminate many foods and especially fruits and fruit‐
based products. Therefore, accurate and effective testing is necessary to enable producers …

Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses

A Dugourd, C Kuppe, M Sciacovelli… - Molecular Systems …, 2021 - embopress.org
Multi‐omics datasets can provide molecular insights beyond the sum of individual omics.
Various tools have been recently developed to integrate such datasets, but there are limited …

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque

A Fernández-Torras, M Duran-Frigola, M Bertoni… - Nature …, 2022 - nature.com
Biomedical data is accumulating at a fast pace and integrating it into a unified framework is a
major challenge, so that multiple views of a given biological event can be considered …

[HTML][HTML] Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis

R Kuraji, T Shiba, TS Dong, Y Numabe… - World journal of …, 2023 - ncbi.nlm.nih.gov
A growing body of evidence from multiple areas proposes that periodontal disease,
accompanied by oral inflammation and pathological changes in the microbiome, induces gut …

[HTML][HTML] Predicting and understanding the response to short-term intensive insulin therapy in people with early type 2 diabetes

YON Lopez, R Retnakaran, B Zinman, RE Pratley… - Molecular …, 2019 - Elsevier
Objective Short-term intensive insulin therapy (IIT) early in the course of type 2 diabetes
acutely improves beta-cell function with long-lasting effects on glycemic control. However …

[HTML][HTML] Footprint-based functional analysis of multiomic data

A Dugourd, J Saez-Rodriguez - Current Opinion in Systems Biology, 2019 - Elsevier
Omic technologies allow us to generate extensive data, including transcriptomic, proteomic,
phosphoproteomic and metabolomic. These data can be used to study signal transduction …

LINT‐web: a web‐based lipidomic data mining tool using intra‐Omic integrative correlation strategy

F Li, J Song, Y Zhang, S Wang, J Wang, L Lin… - Small …, 2021 - Wiley Online Library
Lipidomics is a younger member of the “omics” family. It aims to profile lipidome alterations
occurring in biological systems. Similar to the other “omics”, lipidomic data is highly …

Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle

R Egami, T Kokaji, A Hatano, K Yugi, M Eto, K Morita… - IScience, 2021 - cell.com
Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving
multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic …

Signaling and gene expression in skeletal muscles in type 2 diabetes: current results and OMICS perspectives

AV Vorotnikov, DV Popov, PA Makhnovskii - Biochemistry (Moscow), 2022 - Springer
Skeletal muscles mainly contribute to the emergence of insulin resistance, impaired glucose
tolerance and the development of type 2 diabetes. Molecular mechanisms that regulate …