Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond
Epilepsy is one of the most common and disabling chronic neurological disorders.
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Infections, inflammation and epilepsy
Epilepsy is the tendency to have unprovoked epileptic seizures. Anything causing structural
or functional derangement of brain physiology may lead to seizures, and different conditions …
or functional derangement of brain physiology may lead to seizures, and different conditions …
Animal models of seizures and epilepsy: past, present, and future role for the discovery of antiseizure drugs
W Löscher - Neurochemical research, 2017 - Springer
The identification of potential therapeutic agents for the treatment of epilepsy requires the
use of seizure models. Except for some early treatments, including bromides and …
use of seizure models. Except for some early treatments, including bromides and …
Neuroinflammation and proinflammatory cytokines in epileptogenesis
A Soltani Khaboushan, N Yazdanpanah… - Molecular neurobiology, 2022 - Springer
Increasing evidence corroborates the fundamental role of neuroinflammation in the
development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the …
development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the …
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …
[HTML][HTML] Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective
A Talevi - Frontiers in pharmacology, 2015 - frontiersin.org
Multi-target drugs have raised considerable interest in the last decade owing to their
advantages in the treatment of complex diseases and health conditions linked to drug …
advantages in the treatment of complex diseases and health conditions linked to drug …
Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?
W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …
endothelial cells connected by tight junctions that separate the circulating blood from the …
Indication of dynamic peroxynitrite fluctuations in the rat epilepsy model with a near-infrared two-photon fluorescent probe
Epilepsy is a chronic neurodegenerative disease that has seriously threatened human
health. Accumulating evidence reveals that the pathological progression of epilepsy is …
health. Accumulating evidence reveals that the pathological progression of epilepsy is …
Epilepsy, antiepileptic drugs, and aggression: an evidence-based review
Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …