mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
Chikungunya fever
K Bartholomeeusen, M Daniel, DA LaBeaud… - Nature Reviews …, 2023 - nature.com
Chikungunya virus is widespread throughout the tropics, where it causes recurrent
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …
SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle
L Zimmermann, X Zhao, J Makroczyova… - Nature …, 2023 - nature.com
Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …
Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture
V Kril, M Hons, C Amadori, C Zimberger… - Nature …, 2024 - nature.com
Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that
represent a significant threat to human health due to the current context of global warming …
represent a significant threat to human health due to the current context of global warming …
Molecular architecture of the Chikungunya virus replication complex
To better understand how positive-strand (+) RNA viruses assemble membrane-associated
replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected …
replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected …
New insights into chikungunya virus infection and pathogenesis
V Kril, O Aïqui-Reboul-Paviet, L Briant… - Annual Review of …, 2021 - annualreviews.org
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for
major outbreaks of disease since 2004 in the Indian Ocean islands, South east Asia, and the …
major outbreaks of disease since 2004 in the Indian Ocean islands, South east Asia, and the …
Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1
Chikungunya virus (CHIKV) causes a debilitating arthralgic inflammatory disease in
humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and …
humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and …
A perspective on the prospective use of AI in protein structure prediction
R Versini, S Sritharan, B Aykac Fas… - Journal of Chemical …, 2023 - ACS Publications
AlphaFold2 (AF2) and RoseTTaFold (RF) have revolutionized structural biology, serving as
highly reliable and effective methods for predicting protein structures. This article explores …
highly reliable and effective methods for predicting protein structures. This article explores …
Architecture of the chikungunya virus replication organelle
Alphaviruses are mosquito-borne viruses that cause serious disease in humans and other
mammals. Along with its mosquito vector, the Alphavirus chikungunya virus (CHIKV) has …
mammals. Along with its mosquito vector, the Alphavirus chikungunya virus (CHIKV) has …
Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
Abstract Alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis
virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne …
virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne …