Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common
conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic …

Pseudoxanthoma elasticum (PXE) is a complex autosomal recessive disease caused by
mutations of ABCC6 transporter and characterized by ectopic mineralization of soft …

Overproduction of oxidants in the human body is responsible for oxidative stress, which is
associated with several diseases. High intake of vegetables and fruits can reduce the risk of …

Pseudoxanthoma elasticum (PXE) is a hereditary ectopic calcification disorder affecting the
skin, eyes, and blood vessels. Recently, the DNA damage response (DDR), in particular …

The first intermediate in the mitochondrial tricarboxylic acid (TCA) cycle is citrate, which is
essential and acts as a metabolic regulator for glycolysis, TCA cycle, gluconeogenesis, and …

There is growing evidence that various ATP-binding cassette (ABC) transporters contribute
to the growth and development of tumors, but relatively little is known about how the ABC …

The rapid spread of the new Coronavirus Disease 2019 (COVID-19) has actually become
the newest challenge for the healthcare system since, to date, there is not an effective …

Pseudoxanthoma elasticum (PXE) is a rare autosomal-recessive disorder that is mainly
caused by mutations in the ATP-binding cassette sub-family C member 6 (ABCC6) gene …

Quercetin is a member of the flavonoid group of compounds, which is abundantly present in
various dietary sources. It has excellent antioxidant properties and anti-inflammatory activity …

Ectopic calcification and dysregulated extracellular matrix remodeling are prominent
hallmarks of the complex heterogenous pathobiochemistry of pseudoxanthoma elasticum …