Posttranscriptional modifications of transfer RNAs (tRNAs) are critical for all core aspects of
tRNA function, such as folding, stability, and decoding. Most tRNA modifications were …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

Dysfunction of mitochondrial respiration is an increasingly recognized cause of isolated
hypertrophic cardiomyopathy. To gain insight into the genetic origin of this condition, we …

Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which
are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella …

We report three families presenting with hypertrophic cardiomyopathy, lactic acidosis, and
multiple defects of mitochondrial respiratory chain (MRC) activities. By direct sequencing of …

Withstanding 3.5 billion years of genetic drift, the canonical genetic code remains such a
fundamental foundation for the complexity of life that it is highly conserved across all three …

Among all RNAs, tRNA exhibits the largest number and the widest variety of post-
transcriptional modifications. Modifications within the anticodon stem loop, mainly at the …

In eukaryotes, mitochondrial RNAs (mt-tRNAs and mt-rRNAs) are subject to specific
nucleotide modifications, which are critical for distinct functions linked to the synthesis of …

Abstract In Escherichia coli, the MnmEG complex modifies transfer RNAs (tRNAs) decoding
NNA/NNG codons. MnmEG catalyzes two different modification reactions, which add an …

Transfer RNA (tRNA) is an RNA molecule that carries amino acids to the ribosomes for
protein synthesis. These tRNAs function at the peptidyl (P) and aminoacyl (A) binding sites …