In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

Obesity and diabetes now considered global epidemics. The prevalence rates of diabetes
are increasing in parallel with the rates of obesity and the strong connection between these …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

Epigenetic deregulation has emerged as a driver in human malignancies. There is no clear
understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the …

In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing
circulating LDL cholesterol (LDL-C). Whereas the transcriptional regulation of LDLR is well …

MicroRNAs (miRNAs) regulate a wide variety of biological processes and contribute to
metabolic homeostasis. Here, we demonstrate that microRNA-223 (miR-223), an miRNA …