A perspective on genetic and polygenic risk scores—advances and limitations and overview of associated tools
J Schwarzerova, M Hurta, V Barton… - Briefings in …, 2024 - academic.oup.com
Abstract Polygenetic Risk Scores are used to evaluate an individual's vulnerability to
developing specific diseases or conditions based on their genetic composition, by taking …
developing specific diseases or conditions based on their genetic composition, by taking …
Targeting macrophage metabolism to enhance tumor immunotherapy
J Liu, Z Ma, W Jia, P Lan - Cellular & Molecular Immunology, 2024 - nature.com
Tumor-associated macrophages (TAMs) are important components of the tumor
microenvironment (TME) and are characterized by plasticity and heterogeneity. This …
microenvironment (TME) and are characterized by plasticity and heterogeneity. This …
Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic Modulation
D Williams, E Hargrove-Wiley, W Bindeman… - International Journal of …, 2024 - mdpi.com
Interleukin-4 (IL4) is a Th2 cytokine that can signal through two different receptors, one of
which—the type II receptor—is overexpressed by various cancer cells. Previously, we have …
which—the type II receptor—is overexpressed by various cancer cells. Previously, we have …