Spreading depression, spreading depolarizations, and the cerebral vasculature
C Ayata, M Lauritzen - Physiological reviews, 2015 - journals.physiology.org
Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …
depolarization associated with massive transmembrane ionic and water shifts. It is …
Astrocyte regulation of blood flow in the brain
BA MacVicar, EA Newman - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Neuronal activity results in increased blood flow in the brain, a response named functional
hyperemia. Astrocytes play an important role in mediating this response. Neurotransmitters …
hyperemia. Astrocytes play an important role in mediating this response. Neurotransmitters …
Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain
S Nielsen, EA Nagelhus… - Journal of …, 1997 - Soc Neuroscience
Membrane water transport is critically involved in brain volume homeostasis and in the
pathogenesis of brain edema. The cDNA encoding aquaporin-4 (AQP4) water channel …
pathogenesis of brain edema. The cDNA encoding aquaporin-4 (AQP4) water channel …
Astrocyte control of synaptic transmission and neurovascular coupling
PG Haydon, G Carmignoto - Physiological reviews, 2006 - journals.physiology.org
From a structural perspective, the predominant glial cell of the central nervous system, the
astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the …
astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the …
[HTML][HTML] Functions of astrocytes and their potential as therapeutic targets
HK Kimelberg, M Nedergaard - Neurotherapeutics, 2010 - Elsevier
Astrocytes are often referred to, and historically have been regarded as, support cells of the
mammalian CNS. Work over the last decade suggests otherwise—that astrocytes may in fact …
mammalian CNS. Work over the last decade suggests otherwise—that astrocytes may in fact …
Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord
JE Rash, T Yasumura, CS Hudson… - Proceedings of the …, 1998 - National Acad Sciences
Aquaporin (AQP) water channels are abundant in the brain and spinal cord, where AQP1
and AQP4 are believed to play major roles in water metabolism and osmoregulation …
and AQP4 are believed to play major roles in water metabolism and osmoregulation …
Local potassium signaling couples neuronal activity to vasodilation in the brain
The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral
arterioles to dilate remain obscure. Here we show that modest elevation of extracellular …
arterioles to dilate remain obscure. Here we show that modest elevation of extracellular …
Astrocytes and the regulation of cerebral blood flow
RC Koehler, RJ Roman, DR Harder - Trends in neurosciences, 2009 - cell.com
Moment-to-moment changes in local neuronal activity lead to dynamic changes in cerebral
blood flow. Emerging evidence implicates astrocytes as one of the key players in …
blood flow. Emerging evidence implicates astrocytes as one of the key players in …