The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

JA Scarth, MR Patterson… - Journal of General …, 2021 - microbiologyresearch.org
Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review

SV Graham - Clinical science, 2017 - portlandpress.com
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately
linked to epithelial differentiation. There are over 200 different HPV genotypes identified to …

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: a review

J Sadri Nahand, M Moghoofei… - … journal of cancer, 2020 - Wiley Online Library
Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most
important risk factor for the development of CC is cervical infection with human papilloma …

[HTML][HTML] miR-34–a microRNA replacement therapy is headed to the clinic

AG Bader - Frontiers in genetics, 2012 - frontiersin.org
MicroRNA-34 (miR-34) is a master regulator of tumor suppression. It is downregulated in
numerous cancers and inhibits malignant growth by repressing genes involved in various …

Clinical implications of (epi) genetic changes in HPV-induced cervical precancerous lesions

RDM Steenbergen, PJF Snijders… - Nature Reviews …, 2014 - nature.com
Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in
productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of …

microRNAs: new prognostic, diagnostic, and therapeutic biomarkers in cervical cancer

JS Nahand, S Taghizadeh‐boroujeni… - Journal of cellular …, 2019 - Wiley Online Library
Cervical cancer is as a kind of cancer beginning from the cervix. Given that cervical cancer
could be observed in women who infected with papillomavirus, regular oral contraceptives …

[HTML][HTML] Papillomavirus E6 oncoproteins

SBV Pol, AJ Klingelhutz - Virology, 2013 - Elsevier
Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

Viruses, microRNAs, and host interactions

RL Skalsky, BR Cullen - Annual review of microbiology, 2010 - annualreviews.org
One of the most significant recent advances in biomedical research has been the discovery
of the∼ 22-nt-long class of noncoding RNAs designated microRNAs (miRNAs). These …

Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells

A Honegger, D Schilling, S Bastian, J Sponagel… - PLoS …, 2015 - journals.plos.org
Specific types of human papillomaviruses (HPVs) cause cervical cancer. Cervical cancers
exhibit aberrant cellular microRNA (miRNA) expression patterns. By genome-wide analyses …

HPV16 and HPV18 genome structure, expression, and post-transcriptional regulation

L Yu, V Majerciak, ZM Zheng - International journal of molecular sciences, 2022 - mdpi.com
Human papillomaviruses (HPV) are a group of small non-enveloped DNA viruses whose
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …