In the following section, we will recapitulate selected experimental milestones through the
eyes of the theoretician, which, in our opinion, significantly advanced the field of covalent …

Chemical reactivity underlies our fundamental understanding of many physical and
biological phenomena. Chemical reactions are typically initiated by heat, electric current or …

Here we describe a protocol for using force-clamp spectroscopy to precisely quantify the
effect of force on biochemical reactions. A calibrated force is used to control the exposure of …

This paper presents a comprehensive molecular dynamics study on the effects of
nanocracks (a row of vacancies) on the fracture strength of graphene sheets at various …

Single-molecule fluorescence techniques have emerged as powerful tools to study
biological processes at the molecular level. This review describes the application of these …

Recent force microscopy measurements on the mechanically activated cleavage of a protein
disulfide bond through reaction with hydroxide ions revealed that for forces greater than 0.5 …

Internal motions of folded proteins have been assumed to be ergodic, ie, that the dynamics
of a single protein molecule averaged over a very long time resembles that of an ensemble …

We investigated the temperature and strain rate dependent fracture strength of defective
graphene using molecular dynamics and an atomistic model. This atomistic model was …

Talin as a critical focal adhesion mechanosensor exhibits force-dependent folding dynamics
and concurrent interactions. Being a cytoplasmic protein, talin also might interact with …

How proteins respond to pulling forces, or protein nanomechanics, is a key contributor to the
form and function of biological systems. Indeed, the conventional view that proteins are able …