Proteins are often referred to in accordance with the activity with which they were first
associated or the organelle in which they were initially identified. However, a variety of …

A cell fraction that would today be termed “the nuclear matrix” was first described and
patented in 1948 by Russian investigators. In 1974 this fraction was rediscovered and …

Background: The cell nucleus contains distinct classes of subnuclear bodies, including
nucleoli, splicing speckles, Cajal bodies, gems, and PML bodies. Many nuclear proteins are …

How do cells discriminate between selectively edited mRNAs that encode new protein
isoforms, and dsRNA-induced, promiscuously edited RNAs that encode nonfunctional …

Nephrin is a key functional component of the slit diaphragm, the structurally unresolved
molecular filter in renal glomerular capillaries. Abnormal nephrin or its absence results in …

Nuclei are intricately structured, and nuclear metabolism has an elaborate spatial
organization. The architecture of the nucleus includes two overlapping and nucleic-acid …

P54nrb is a protein implicated in multiple nuclear processes whose specific functions may
correlate with its presence at different nuclear locations. Here we characterize paraspeckles …

Electron tomography of thin sections of plastic-embedded biological material provides
valuable insights into the organellar organization of cells. With the advent of automated data …

In contrast to averaging methods of determining structure, such as X-ray diffraction, NMR,
and single-particle tomography, cryo-electron tomography allows three-dimensional …

Nephrin is a type-1 transmembrane protein and a key component of the podocyte slit
diaphragm, the ultimate glomerular plasma filter. Genetic and acquired diseases affecting …