Malignant brain tumours continue to be the cause of a disproportionate level of morbidity
and mortality across a wide range of individuals. The most common variants in the adult and …

Childhood tumors containing cells that are morphologically and functionally similar to
normal progenitor cells provide fertile ground for investigating the links between …

PURPOSE SJMB03 (ClinicalTrials. gov identifier: NCT00085202) was a phase III risk-
adapted trial that aimed to determine the frequency and clinical significance of biological …

Nearly one-third of children with medulloblastoma, a malignant embryonal tumor of the
cerebellum, succumb to their disease. Conventional response monitoring by imaging and …

Purpose Recent genomic approaches have suggested the existence of multiple distinct
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine …

Cancers are believed to arise from cancer stem cells (CSCs), but it is not known if these cells
remain dependent upon the niche microenvironments that regulate normal stem cells. We …

Purpose To determine the event-free survival (EFS) and overall survival of children with
average-risk medulloblastoma and treated with reduced-dose craniospinal radiotherapy …

Purpose Medulloblastoma is the most common malignant brain tumor in children. Current
treatment decisions are based on clinical variables. Novel tumor-derived biomarkers may …

Medulloblastoma is the most common malignant brain tumour that occurs during childhood.
Multimodality treatment regimens have substantially improved survival in this disease; …

Medulloblastoma is an aggressive brain malignancy with high incidence in childhood.
Current treatment approaches have limited efficacy and severe side effects. Therefore, new …