Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001–2011)
J Wang, M Sánchez-Roselló, JL Aceña… - Chemical …, 2014 - ACS Publications
1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …
Chiral 1, 1-diaryl compounds as important pharmacophores
D Ameen, TJ Snape - MedChemComm, 2013 - pubs.rsc.org
Compounds containing a 1, 1-diaryl motif are numerous, and compounds of this type have
found use as catalysts and molecular building blocks, however, this review focusses solely …
found use as catalysts and molecular building blocks, however, this review focusses solely …
Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects
K Wu, AG Doyle - Nature chemistry, 2017 - nature.com
The field of Ni-catalysed cross-coupling has seen rapid recent growth because of the low
cost of Ni, its earth abundance, and its ability to promote unique cross-coupling reactions …
cost of Ni, its earth abundance, and its ability to promote unique cross-coupling reactions …
Dialkyl Ether Formation by Nickel‐Catalyzed Cross‐Coupling of Acetals and Aryl Iodides
KM Arendt, AG Doyle - Angewandte Chemie, 2015 - Wiley Online Library
A new substrate class for nickel‐catalyzed C (sp3) cross‐coupling reactions is reported. α‐
Oxy radicals generated from benzylic acetals, TMSCl, and a mild reductant can participate in …
Oxy radicals generated from benzylic acetals, TMSCl, and a mild reductant can participate in …
Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures
Sertraline and fluoxetine are selective serotonin re-uptake inhibitors (SSRIs) that are widely
prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma …
prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma …
Recent advances towards the synthesis of dihydrobenzofurans and dihydroisobenzofurans
AB Dapkekar, C Sreenivasulu… - Asian Journal of …, 2022 - Wiley Online Library
Abstract The 2, 3‐dihydrobenzofuran heterocyclic systems are found in various biologically
active natural and pharmaceutical products of biological relevance such as Phalarine …
active natural and pharmaceutical products of biological relevance such as Phalarine …
Rhodium‐Catalyzed, Highly Enantioselective 1, 2‐Addition of Aryl Boronic Acids to α‐Ketoesters and α‐Diketones Using Simple, Chiral Sulfur–Olefin Ligands
TS Zhu, SS Jin, MH Xu - Angewandte Chemie International Edition, 2012 - infona.pl
Simply the best: The title reaction has been achieved by asymmetric rhodium catalysis
employing an extremely simple, chiral N‐(sulfinyl) cinnamylamine ligand. A variety of highly …
employing an extremely simple, chiral N‐(sulfinyl) cinnamylamine ligand. A variety of highly …
Catalytic Lactonization of Unactivated Aryl C–H Bonds with CO2: Experimental and Computational Investigation
L Song, L Zhu, Z Zhang, JH Ye, SS Yan, JL Han… - Organic …, 2018 - ACS Publications
The first catalytic lactonization of unactivated aryl C–H bonds with CO2 to afford important
phthalides is reported. Notably, this method features high selectivity, excellent functional …
phthalides is reported. Notably, this method features high selectivity, excellent functional …
Simple sulfur–olefins as new promising chiral ligands for asymmetric catalysis
Y Li, MH Xu - Chemical Communications, 2014 - pubs.rsc.org
Since 2003, the discovery of chiral dienes as steering ligands in asymmetric processes has
opened the field of chiral chelating olefin catalysis. However, despite the impressive …
opened the field of chiral chelating olefin catalysis. However, despite the impressive …
Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters
J Andersen, AS Kristensen, B Bang-Andersen… - Chemical …, 2009 - pubs.rsc.org
The biogenic monoamine transporters are integral membrane proteins that perform active
transport of extracellular dopamine, serotonin and norepinephrine into cells. These …
transport of extracellular dopamine, serotonin and norepinephrine into cells. These …