CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …
promising immunotherapeutic approach to fight cancers. This approach consists of …
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …
The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors
K Hadiloo, S Taremi, M Heidari, A Esmaeilzadeh - Biomarker Research, 2023 - Springer
Today, adoptive cell therapy has many successes in cancer therapy, and this subject is
brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA …
brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA …
Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies
S Shetab Boushehri, K Essig, NK Chlis, S Herter… - Nature …, 2023 - nature.com
Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune
cells and act within the immunological synapse; an essential cell-to-cell interaction to direct …
cells and act within the immunological synapse; an essential cell-to-cell interaction to direct …
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant
potential for managing inflammatory disorders like asthma. Activating iNKT induces …
potential for managing inflammatory disorders like asthma. Activating iNKT induces …
Antigen loss following CAR‐T cell therapy: Mechanisms, implications, and potential solutions
Abstract Chimeric Antigen Receptor T‐cell (CAR‐T cell) therapy has emerged as a
groundbreaking immunotherapeutic approach for treating various hematological …
groundbreaking immunotherapeutic approach for treating various hematological …
Elaborating the potential of Artificial Intelligence in automated CAR-T cell manufacturing
N Bäckel, S Hort, T Kis, DF Nettleton… - Frontiers in Molecular …, 2023 - frontiersin.org
This paper discusses the challenges of producing CAR-T cells for cancer treatment and the
potential for Artificial Intelligence (AI) for its improvement. CAR-T cell therapy was approved …
potential for Artificial Intelligence (AI) for its improvement. CAR-T cell therapy was approved …
The transformative potential of AI-driven CRISPR-Cas9 genome editing to enhance CAR T-cell therapy
A Boretti - Computers in Biology and Medicine, 2024 - Elsevier
This narrative review examines the promising potential of integrating artificial intelligence
(AI) with CRISPR-Cas9 genome editing to advance CAR T-cell therapy. AI algorithms offer …
(AI) with CRISPR-Cas9 genome editing to advance CAR T-cell therapy. AI algorithms offer …
[HTML][HTML] An examination of process models and model risk frameworks for pharmaceutical manufacturing
T O'Connor, S Chatterjee, J Lam… - International Journal of …, 2024 - Elsevier
Process models are a growing tool for pharmaceutical manufacturing process design and
control. The Industry 4.0 paradigm promises to increase the amount of data available to …
control. The Industry 4.0 paradigm promises to increase the amount of data available to …