Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has
been linked to an elevated risk for many chronic diseases. The discovery of myokines …

Depression is a debilitating condition with a profound impact on quality of life for millions of
people worldwide. Physical exercise is used as a treatment strategy for many patients, but …

Recent studies have indicated that the regulation of innate immunity and energy metabolism
are connected together through an antagonistic crosstalk between NF-κB and SIRT1 …

Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …

Mechanical stimulation (mechanotherapy) can promote skeletal muscle repair, but a lack of
reproducible protocols and mechanistic understanding of the relation between mechanical …

Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …

Mammalian skeletal muscles are composed of a variety of highly specialized fibers whose
selective recruitment allows muscles to fulfill their diverse functional tasks. In addition …

Background & Aims Inefficient fatty acid oxidation in mitochondria and increased oxidative
damage are features of non-alcoholic fatty liver disease (NAFLD). In rodent models and …