Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …

Zebrafish has become a popular model to study many physiological and pathophysiological
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …

Background Heart failure (HF) and dementia frequently co-exist with shared pathological
mechanisms and risk factors. Our study aims to investigate the association between statin …

Brain glucose hypometabolism is a significant manifestation of Alzheimer's disease (AD). 27-
hydroxycholesterol (27-OHC) and the gut microbiota have been recognized as factors …

Alzheimer's disease (AD) is the most common cause of dementia. A genome‐wide
association study has shown that several AD risk genes are involved in lipid metabolism …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide and
has a high incidence in the elderly. Unfortunately, there is no effective therapy for AD owing …

Significance: Cholesterol plays a crucial role in the brain, where it is highly concentrated and
tightly regulated to support normal brain functions. It serves as a vital component of cell …

An incurable neurogenerative illness, Alzheimer's disease, is the cause of most global
health, medical, and social disasters. The two main symptoms are cognitive impairment and …

Alzheimer's disease (AD) is a complex neurological ailment that causes cognitive decline
and memory loss. Cholesterol metabolism dysregulation has emerged as a crucial element …

One of the major obstacles confronting the formulation of a mechanistic understanding for
Alzheimer's disease (AD) is its immense complexity—a complexity that traverses the full …