The generation of phagosomal cytotoxic reactive species (ie, free radicals and oxidants) by
activated macrophages and neutrophils is a crucial process for the control of intracellular …

Low molecular weight (LMW) thiols play an important role as thiol-cofactors for many
enzymes and are crucial to maintain the reduced state of the cytoplasm. Most Gram-negative …

The Mycobacterium tuberculosis (Mtb) VapBC4 toxin–antitoxin system is essential for the
establishment of Mtb infection. Using a multitier, systems-level approach, we uncovered the …

Bacteria respond to nutrient starvation implementing the stringent response, a stress
signaling system resulting in metabolic remodeling leading to decreased growth rate and …

Tuberculosis (TB) is a major global health challenge, with approximately 1.4 million deaths
per year. There is still a need to develop novel treatments for patients infected with …

The emergence of drug-resistant Mycobacterium tuberculosis strains highlights the need to
discover anti-tuberculosis drugs with novel mechanisms of action. Here we discovered a …

The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro
group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes …

Significance: Decrypting the cellular response to oxidative stress relies on a comprehensive
understanding of the redox signaling pathways stimulated under oxidizing conditions …

As an efficient and safe industrial bacterium, Corynebacterium glutamicum has extensive
application in amino acid production. However, it often faces oxidative stress induced by …

The success of Mycobacterium tuberculosis (Mtb) as a pathogen depends on the redundant
and complex mechanisms it has evolved for resisting nitrosative and oxidative stresses …