The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …

Coupled biological and chemical systems, neural networks, social interacting species, the
Internet and the World Wide Web, are only a few examples of systems composed by a large …

Genome-scale human protein–protein interaction networks are critical to understanding cell
biology and interpreting genomic data, but challenging to produce experimentally. Through …

A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …

Background Recent advances in proteomics technologies such as two-hybrid, phage
display and mass spectrometry have enabled us to create a detailed map of biomolecular …

Access to unified datasets of protein and genetic interactions is critical for interrogation of
gene/protein function and analysis of global network properties. BioGRID is a freely …

A fundamental challenge in human health is the identification of disease-causing genes.
Recently, several studies have tackled this challenge via a network-based approach …

Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. Here we report the first genome-wide screen for complexes in an …

A genetic interaction network containing∼ 1000 genes and∼ 4000 interactions was
mapped by crossing mutations in 132 different query genes into a set of∼ 4700 viable gene …

Background A global map of protein-protein interactions in cellular systems provides key
insights into the workings of an organism. A repository of well-validated high-quality protein …