3D cell culture systems: tumor application, advantages, and disadvantages
O Habanjar, M Diab-Assaf, F Caldefie-Chezet… - International journal of …, 2021 - mdpi.com
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …
been used in cancer research. However, this system cannot be fully translated into clinical …
Hydrogels as drug delivery systems: A review of current characterization and evaluation techniques
Owing to their tunable properties, controllable degradation, and ability to protect labile
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …
How the ageing microenvironment influences tumour progression
M Fane, AT Weeraratna - Nature Reviews Cancer, 2020 - nature.com
Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …
and reaching older ages, cancer is becoming a substantial public health problem. It is …
Impact of the physical microenvironment on tumor progression and metastasis
Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …
Interactions between hyaluronan and its receptors (CD44, RHAMM) regulate the activities of inflammation and cancer
S Misra, VC Hascall, RR Markwald… - Frontiers in …, 2015 - frontiersin.org
The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
Mesenchymal–epithelial transition in development and reprogramming
During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–
mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can …
mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can …
Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …
Three-dimensional cell culture: the missing link in drug discovery
S Breslin, L O'Driscoll - Drug discovery today, 2013 - Elsevier
Cells, grown as monolayers (2D models), are routinely used as initial model systems for
evaluating the effectiveness and safety of libraries of molecules with potential as therapeutic …
evaluating the effectiveness and safety of libraries of molecules with potential as therapeutic …
[HTML][HTML] Biophysics of tumor microenvironment and cancer metastasis-a mini review
The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …