Eye is the unique sense organ with complex and sophisticated anatomy and physiology.
Being most instrumental for vision, it is secured by varied protective barriers; ranging from …

Small interfering RNA (siRNA) is a potential method of gene silencing to target specific
genes. Although the US Food and Drug Administration (FDA) has approved multiple siRNA …

Since the evolutionary discovery of RNA interference and its utilization for gene knockdown
in mammalian cell, a remarkable progress has been achieved in small interfering RNA …

Glaucoma is the result of the gradual death of retinal ganglion cells (RGCs) whose axons
form the optic nerve. Elevated intraocular pressure (IOP) is a major risk factor that …

Diatoms are unicellular photosynthetic algae enclosed in porous 3D nanopatterned silica
enclosures called “frustules.” The diatom frustules are made from biosilica self‐assembled …

Given the successful entry of several liposomal drug products into market, and some with
decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to …

Melphalan is an efficient chemotherapeutic agent that is currently used to treat
retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous …

Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration
surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but …

Considerable adverse side effects and cytotoxicity of highly potent drugs for healthy tissue
require the development of novel drug delivery systems to improve pharmacokinetics and …

Activation of hepatic stellate cells (HSC) is a hallmark event in liver fibrosis. Accumulation of
reactive oxygen species (ROS) serves as a driving force for HSC activation. The regulatory …