To better understand the quantitative characteristics and structure of phenotypic diversity, we
measured over 14,000 transcript, protein, metabolite, and morphological traits in 22 …

Copper homeostasis is an important determinant for virulence of many human pathogenic
fungi such as the highly prevalent yeast Candida albicans. However, beyond the copper …

Thiolase plays important roles in lipid metabolism. It can be divided into degradative
thiolases (thioase I) and biosynthetic thiolases (thiolases II), which are involved in fatty acid …

Abstract Background The yeast Saccharomyces cerevisiae can be a useful model for
studying cellular mechanisms related to sterol synthesis in humans due to the high similarity …

We recently demonstrated that statins mediate protection against intracellular pathogens,
Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here, we investigated the …

The synergistic combinations of drugs are promising strategies to boost the effectiveness of
current antifungals and thus prevent the emergence of resistance. In this work, we show that …

Aims Enhancement of the tolerance of Saccharomyces cerevisiae to monoterpenes has the
potential to improve the de novo biosynthesis of these chemicals as well as the efficient …

Pravastatin (PRV), a lipid-lowering medication, is prescribed to treat cardiovascular disease
and dyslipidemia. Due to its low permeability and high solubility, the biopharmaceutics …

The COP 9 signalosome (CSN) is a highly conserved eukaryotic protein complex which
regulates the cullin RING family of ubiquitin ligases and carries out a deneddylase activity …

Mevalonate diphosphate decarboxylase (MVD; EC 4.1. 1.33) is a key enzyme of the
mevalonic acid (MVA) pathway. In fungi, the MVA pathway functions as upstream of …