Aldosterone is the major mineralocorticoid synthesized by the adrenal and plays an
important role in the regulation of systemic blood pressure through the absorption of sodium …

Aldosterone, the primary human mineralocorticoid, is a major regulator of intravascular
volume and blood pressure. The capacity of the adrenal gland to produce aldosterone is …

Up to 15% of patients with essential hypertension have inappropriate regulation of
aldosterone; although only a minority have distinct adrenal tumors, recent evidence shows …

Aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex is regulated by
transcription of CYP11B2 (encoding aldosterone synthase). The effects of nerve growth …

Comμlement‐Clq TNF‐related protein 1 (CTRP1), a member of the CTRP superfamily, is
expressed at high levels in adipose tissues of obese Zucker diabetic fatty (fa/fa) rats, and …

The steroidogenic acute regulatory protein is indispensable for the biosynthesis of steroid
hormones. Steroidogenic acute regulatory protein mediates the rate-limiting step in …

The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and
stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis …

The type 1 parathyroid hormone receptor (PTHR1) binds, with equal affinity, two ligands with
distinct biological functions: PTH, the major peptide hormone controlling calcium …

Abstract Aldosterone synthase (CYP11B2) is expressed in the adrenal glomerulosa and
controls the capacity of the adrenal glomerulosa to produce aldosterone. Herein, human NCI …

Context: Excess production of aldosterone or cortisol has profound effects on cardiovascular
function and impacts other major organ systems. The mechanisms leading to the …