All animal embryos pass through a stage during which developmental control is handed
from maternally provided gene products to those synthesized from the zygotic genome. This …

The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-
kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major …

Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated …

Germline stem cells play a pivotal role in gametogenesis; yet little is known about how they
are formed, how they divide to self-renew, and how these processes are genetically …

Abstract mRNA localization is a common mechanism for targeting proteins to regions of the
cell where they are required. It has an essential role in localizing cytoplasmic determinants …

As highlighted by recent genome-wide analyses in diverse organisms and cell types,
subcellular targeting of mRNAs has emerged as a major mechanism for cells to establish …

Intracellular targeting of mRNAs has long been recognized as a means to produce proteins
locally, but has only recently emerged as a prevalent mechanism used by a wide variety of …

Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of
establishing spatially restricted protein synthesis. The characterization of cis-acting signals …

The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …

In animals, egg activation triggers a cascade of posttranscriptional events that act on
maternally synthesized RNAs. We show that, in Drosophila, the PAN GU (PNG) kinase sits …