Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from
a complicated evolutionary process that assigned it many physiological roles. The main …

Significance: Enhanced levels of reactive oxygen species (ROS) have been associated with
different disease states. Most attempts to validate and exploit these associations by chronic …

The lifetime risk of kidney disease in people with diabetes is 10–30%, implicating genetic
predisposition in the cause of diabetic kidney disease (DKD). Here we identify an …

Renal fibrosis is a common feature of renal failure resulting from multiple etiologies,
including diabetic nephropathy, hypertension and inherited renal disorders. However, the …

Hereditary xanthinuria (HXAN) is a rare metabolic disorder that results from mutations in
either the xanthine dehydrogenase (XDH) or the molybdenum cofactor sulfurase genes …

The development of the kidney involves essential cellular processes, such as cell
proliferation and differentiation, which are led by interactions between multiple signaling …

Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in
extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic …

Non-syndromic kyphosis is a common disorder that is associated with significant morbidity
and has a strong genetic involvement; however, the causative genes remain to be identified …

Durante el desarrollo de esta Tesis, utilizamos modelos de pez cebra para estudiar el
impacto de la Dual Oxidasa 1 (Duox1) y la Xantina deshidrogenasa (Xdh), dos de las …

Kyphosis and scoliosis are common spinal disorders that occur as part of complex
syndromes or as nonsyndromic, idiopathic diseases. Familial and twin studies implicate …