The protective mechanism of TFAM on mitochondrial DNA and its role in neurodegenerative diseases
Y Song, W Wang, B Wang, Q Shi - Molecular Neurobiology, 2024 - Springer
Mitochondrial transcription factor A (TFAM) is a mitochondrial protein encoded by nuclear
genes and transported from the cytoplasm to the mitochondria. TFAM is essential for the …
genes and transported from the cytoplasm to the mitochondria. TFAM is essential for the …
Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First?
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …
The SMYD3-MTHFD1L-formate metabolic regulatory axis mediates mitophagy to inhibit M1 polarization in macrophages
W Zhu, C Wang, L Xue, L Liu, X Yang, Z Liu… - International …, 2022 - Elsevier
Background SMYD3 (protein 3 containing SET and MYND structural domains) belongs to
the SMYD methylesterase family and is a histone lysine methyltransferase that promotes …
the SMYD methylesterase family and is a histone lysine methyltransferase that promotes …
KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy
C de Talhouët, N Esteras, MPM Soutar… - Scientific Reports, 2024 - nature.com
It has recently been shown that KAT8, a genome-wide association study candidate risk gene
for Parkinson's Disease, is involved in PINK1/Parkin-dependant mitophagy. The KAT8 gene …
for Parkinson's Disease, is involved in PINK1/Parkin-dependant mitophagy. The KAT8 gene …
Identification of BAG5 as a Potential Biomarker for Parkinson's Disease Patients With R492X PINK1 Mutation
Parkinson's disease (PD) is a degenerative, progressive nervous system disorder with an
unknown cause. PINK1 [phosphatase and tensin homolog deleted on chromosome 10 …
unknown cause. PINK1 [phosphatase and tensin homolog deleted on chromosome 10 …
KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy
C de Talhouët, N Esteras Gallego, M Soutar… - bioRxiv, 2023 - biorxiv.org
It has recently been shown that KAT8, a genome-wide association study (GWAS) candidate
risk gene for Parkinson's Disease, is involved in PINK1/Parkin-dependant mitophagy. The …
risk gene for Parkinson's Disease, is involved in PINK1/Parkin-dependant mitophagy. The …